Current Issue : April - June Volume : 2020 Issue Number : 2 Articles : 5 Articles
In this work, the supercritical antisolvent (SAS) process was used to coprecipitate Eudragit\nL100-55 (EUD) with diclofenac (DICLO) and theophylline (THEOP), with the aim of obtaining\ncomposite microparticles with a prolonged drug release for oral delivery.............................
Naturally sourced products introduced to human nutrition and rediscovered for therapy\ninclude polysaccharides from potatoes................................
Core-shell beads loaded with betamethasone were developed using co-axial prilling as\nproduction technique and pectin plus alginate as polymeric carriers. During this study, many\noperative conditions were intensively investigated to find the best ones necessary to produce\nuniform core-shell particle systems in a reproducible way. Particularly, feed solutionsâ?? composition,\npolymers mass ratios and the effect of the main process parameters on particles production,\nmicromeritics, inner structure, drug loading and drug-release/swelling profiles in simulated\nbiological fluids were studied..........................................
Polysorbates 20 and 80 are the most frequently used excipients in biotherapeutics, the\nsafety data for which have been well documented in adults. The polysorbate content in therapeutic\nformulations that are administered to children, however, has been less clearly regulated or defined\nwith regard to safety. In pediatric patients, excessive amounts of polysorbate in biotherapeutics\nhave been linked to hypersensitivity and other toxicity-related effects.................................
The treatment of diseases that affect the central nervous system (CNS) represents a great\nresearch challenge due to the restriction imposed by the blood-brain barrier (BBB) to allow the passage\nof drugs into the brain...........................................
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